(7) We sought to replicate these prospective findings in the large WHI cohort, for which important potential confounders, e.g. View details for Web of Science ID 000357901600008. Lin, C. Y., Carneal, E. E., Lichtensztajn, D. Y., Gomez, S. L., Clarke, C. A., Jensen, K. C., Kurian, A. W., Allison, K. H. What Factors Influence Women's Perceptions of their Systemic Recurrence Risk after Breast Cancer Treatment? However, CTC transcriptional profiling is limited by leukocyte contamination; an approach to surmount this problem is single cell analysis. Most studies did not account for gender-specific prediction. Results Six hundred sixty-six patients reported genetic testing. For BRCA1 and BRCA2, we also compared variant interpretations in traditional reports to those produced using only non-proprietary resources and following criteria based on recent (2015) guidelines. Variation in surgeon attitudes about genetic testing and counseling may explain a substantial amount of this association. View details for DOI 10.1093/jncics/pkab090, View details for PubMedCentralID PMC8692829. Relapsed patients in the most expensive surveillance CCPD group had significantly shorter survival.We developed a method to identify high-value oncology care-cost of care per patient per day (CCPD)-in episodes of initial, survivorship, and relapse care. View details for DOI 10.1200/JCO.2006.06.3081, View details for Web of Science ID 000244384000006. We highlight results for one scenario where treatment choice may be uncertain.Chemoendocrine versus endocrine therapy in a 65-69-year-old woman with a small ( 2 cm), intermediate-grade tumor, and mild comorbidities provides a 1.3% absolute reduction in 10-year distant recurrence risk, with 0.23 life-years gained. RSNA, 2013 Online supplemental material is available for this article. In order to explore women's preferences for management of elevated cancer risk, we evaluated the decisions of BRCA1/2 mutation carriers about contraception, prophylactic surgery, and family planning.An internet-based questionnaire assessing high-risk women's preferences about cancer risk management and reproductive options was designed, pilot-tested and administered electronically to 284 participants of an internet-based advocacy group for women with BRCA1/2 mutations.Two hundred and thirteen eligible participants completed the majority of the survey. For more information, please contact Annabel Castaneda, 650-498-7977. Results are conflicting in Asian populations. View details for DOI 10.1158/1055-9965.EPI-14-1140. View details for DOI 10.1158/1055-9965.EPI-12-0149. This Phase Ib-IIa, multi-institutional, open-label, dose-escalation study is designed to The expected regional variability in percent human epidermal growth factor receptor 2 (HER2)-positive breast cancers is not currently clear.Data from the 2006 to 2011 California Cancer Registry were examined by county and health service area. For ER-/PR- disease, BC-specific mortality did not differ by race/ethnicity and associations of race/ethnicity with BC-specific mortality varied only by neighborhood SES among African American women.Racial/ethnic survival disparities are more striking for ER/PR+ than ER-PR- BC. Additionally, two large studies reported increased all-cancer survival with statin use. One-year adjuvant trastuzumab (AT) therapy, with or without anthracyclines, increases disease-free and overall survival in early-stage HER2/neu-positive breast cancer. Polygenic risk scores (PRSs) for breast cancer (BC) risk stratification have been developed primarily in women of European ancestry. Stanford is currently not accepting patients for this trial. Allison, K. H., Jensen, K., West, R., Clarke, C. A., Gomez, S. L., Kurian, A. W. Beyond Barriers: Systemic Constraints Limiting Sexual Health Care for Breast Cancer Survivors. Preliminary information about the View details for DOI 10.1177/09622802211047346, Breast cancer patients increasingly undergo genetic testing. Over half of women reported that doctors used words and numbers to describe risk, while 24% used only words. Most NAC recipients (68.4%) had mastectomies, and 14.3% of them underwent BLM. Cox proportional hazards models were used to calculate hazard ratios (HR) and 95% confidence intervals (CI) for breast cancer-specific mortality.After adjustment for patient, tumor and treatment characteristics, outcomes were comparable by race for Stage I or IV cancer regardless of subtype, and HR+/HER2+ or HR-/HER2+ cancer regardless of stage. The use of common inputs also enhances inferences about the results, and provides a range of reasonable results based on variations in model structure, assumptions, and methods of use of the input values. Friese, C. R., Harrison, J. M., Janz, N. K., Jagsi, R., Morrow, M., Li, Y., Hamilton, A. S., Ward, K. C., Kurian, A. W., Katz, S. J., Hofer, T. P. Tumor BRCA1 Reversion Mutation Arising During Neoadjuvant Platinum-Based Chemotherapy in Triple-Negative Breast Cancer Is Associated with Therapy Resistance. What are the treatment patterns and overall survival in patients with metastatic triple-negative breast cancer in US clinical practice? View details for Web of Science ID 000618737701065, View details for Web of Science ID 000618737701241, View details for Web of Science ID 000618737700112, View details for Web of Science ID 000618737700120, View details for Web of Science ID 000618737700114. B., Cristofanilli, M., Kurian, A. W., Ford, J. M., Balch, A., Watkins, J., Phillips, K. A. Macrophages Promote Circulating Tumor Cell-Mediated Local Recurrence following Radiotherapy in Immunosuppressed Patients. Impact of the COVID-19 Pandemic on Breast Cancer Mortality in the US: Estimates From Collaborative Simulation Modeling. Kurian, A. W., Hughes, E., Handorf, E., et al. On the other hand, Mr. Kurians other twin George moved to Boston to work for internet network company Akamai. Chen, Y., Kingham, K., Ford, J. M., Rosing, J., Van Dam, J., Jeffrey, R. B., Longacre, T. A., Chun, N., Kurian, A., Norton, J. Former Oracle executive Thomas Kurian replaces Diane Greene, the current CEO of Google Cloud. We tested whether the use of RS seems to guide chemotherapy receipt across different cancer care settings.We developed a retrospective cohort of patients with breast cancer by using electronic medical record data from Stanford University (hereafter University) and Palo Alto Medical Foundation (hereafter Community) linked with demographic and staging data from the California Cancer Registry and RS results from the testing laboratory (Genomic Health Inc., Redwood City, CA). The impact of significant others on breast cancer patients treatment decision making. Circulating tumor cells (CTCs) are rare cells found in the blood of patients with solid tumors and may play a key role in cancer dissemination. Caswell-Jin, J. L., Shafaee, M. N., Xiao, L., Liu, M., John, E. M., Bondy, M. L., Kurian, A. W. Relevance of the MHC region for breast cancer susceptibility in Asians. However, she will continue working with Mr. Kurianthrough January to ensure a smooth transition. We focused on US payers because analyses of coverage approaches and policies in the large and complex US health care system may inform similar efforts in other countries. Clinical guidelines recommend breast-conserving surgery (BCS) with radiation as a viable alternative to mastectomy for treatment of early-stage breast cancer. The base case used treatment efficacy measures reported in the randomized clinical trials of AT. Social determinants and lifestyle factors may explain some of the survival disparities for ER/PR+ BC.Addressing these factors may help reduce the higher mortality of African American women with ER/PR+ BC. Similar to IDC, multigene panel testing may be appropriate for women with ILC, but CDH1 should be specifically discussed because of low prevalence and gastric cancer risk. Regression models examined factors associated with chemotherapy recommendations and receipt by the RS and subgroups.There were 1527 patients with stage I/II, estrogen receptor/progesterone receptor-positive, human epidermal growth factor 2-negative disease: 778 received an RS (62.6% of patients with node-negative, favorable disease, 24.3% of patients with node-negative, unfavorable disease, and 13.0% of patients with node-positive disease; P, View details for Web of Science ID 000394719100007. Patients and health care providers rated the decision tool highly on measures of usability and clinical relevance. Based on these image features, we used unsupervised consensus clustering to identify robust imaging subtypes, and evaluated their clinical and biological relevance. Up to 30% of families with HDGC have mutations in the E-cadherin gene, CDH1. Associated breast and ovarian cancer risks ranged from two- to 40-fold after controlling for family history. Friese, C. R., Li, Y., Bondarenko, I., Hofer, T. P., Ward, K. C., Hamilton, A. S., Deapen, D., Kurian, A. W., Katz, S. J. A cox proportional hazards model was used to evaluate survival while controlling for clinical and demographic factors.The best survival pattern was observed among women with HR+/HER2- subtype (survival rate of 92.5% at four years), followed by HR+/HER2+ (90.3%), HR-/HER2+ (82.7%), and finally worst survival for triple-negative subtype (77.0%). Sequencing results were confirmed by in-house developed full high resolution DNA melting (HRM) analysis. Vigen, C., Gomez, S. L., Sposto, R., Lu, Y., Kwan, M., John, E., Monroe, K., Keegan, T. H., Shariff-Marco, S., Kurian, A. W. Oncoshare: lessons learned from building an integrated multi-institutional database for comparative effectiveness research. Results were adjusted for multiple hypothesis testing. B., Eliassen, A. H., Eriksson, M. n., Evans, D. G., Fasching, P. A., Figueroa, J. n., Fritschi, L. n., Gabrielson, M. n., Gago-Dominguez, M. n., Gao, C. n., Gapstur, S. M., Gaudet, M. M., Giles, G. G., Gonzlez-Neira, A. n., Gunel, P. n., Haeberle, L. n., Haiman, C. A., Hkansson, N. n., Hall, P. n., Hamann, U. n., Hatse, S. n., Heyworth, J. n., Holleczek, B. n., Hoover, R. N., Hopper, J. L., Howell, A. n., Hunter, D. J., John, E. M., Jones, M. E., Kaaks, R. n., Keeman, R. n., Kitahara, C. M., Ko, Y. D., Koutros, S. n., Kurian, A. W., Lambrechts, D. n., Marchand, L. L., Lee, E. n., Lejbkowicz, F. n., Linet, M. n., Lissowska, J. n., Llaneza, A. n., MacInnis, R. J., Martinez, M. E., Maurer, T. n., McLean, C. n., Neuhausen, S. L., Newman, W. G., Norman, A. n., O'Brien, K. M., Olshan, A. F., Olson, J. E., Olsson, H. n., Orr, N. n., Perou, C. M., Pita, G. n., Polley, E. C., Prentice, R. L., Rennert, G. n., Rennert, H. S., Ruddy, K. J., Sandler, D. P., Saunders, C. n., Schoemaker, M. J., Schttker, B. n., Schumacher, F. n., Scott, C. n., Scott, R. J., Shu, X. O., Smeets, A. n., Southey, M. C., Spinelli, J. J., Stone, J. n., Swerdlow, A. J., Tamimi, R. M., Taylor, J. Breast cancer was the most common diagnosis (n=67; 21.5%). Use of the 21-gene recurrence score (RS) did not change among node-negative/micrometastasis patients, and increasing RS use in node-positive patients accounted for one-third of the chemotherapy decline. Treatment and monitoring options for patients with metastatic breast cancer (MBC) are increasing, but little is known about variability in care. Between April 2015 and May 2016, 488 surgeons were surveyed regarding lumpectomy margins; 342 (70%) responded completely. Stanford is currently not accepting patients for this trial. Surgery after initial lumpectomy declined by 16% (P. The NCCN Clinical Practice Guidelines in Oncology for Genetic/Familial High-Risk Assessment: Breast and Ovarian provide recommendations for genetic testing and counseling for hereditary cancer syndromes and risk management recommendations for patients who are diagnosed with a syndrome. Notably, failing to impute cases with missing receptor status leads to overestimation of survival because those with missing receptor status tend to have worse prognostic features. Kurian, A. W., Ward, K. C., Howlader, N., Deapen, D., Hamilton, A. S., Mariotto, A., Miller, D., Katz, S. J., Penberthy, L. Unmet need for clinician engagement about financial toxicity after diagnosis of breast cancer. Participants Sub-analyses of the c.7271T>G missense PV were conducted. The women underwent genetic testing within 3 months after diagnosis and were reported to the Georgia and California SEER registries by December 1, 2017.Pathogenic variant status based on linked results of clinical germline genetic testing by 4 laboratories that did most such testing in the studied regions.Potential deviation of treatment from practice guidelines was assessed in the following clinical scenarios: (1) surgery: receipt of bilateral mastectomy by women eligible for less extensive unilateral surgery (unilateral breast tumor); (2) radiotherapy: omission in women indicated for postlumpectomy radiotherapy (all lumpectomy recipients except age 70 with stage I, estrogen and/or progesterone receptor [ER/PR] positive, ERBB2 [formerly HER2]-negative disease); and (3) chemotherapy: receipt by women eligible to consider chemotherapy omission (stages I-II, ER/PR-positive, ERBB2-negative, and 21-gene recurrence score of 0-30, which was the upper limit of the intermediate risk range during the study years). Studies on specific cancer types in relation to cancer use have also been mixed, though the most promising results appear to be found in gastrointestinal cancers. View details for DOI 10.1158/1055-9965.EPI-15-1326. Kurian, A. W., Whittemore, A. S., Ford, J. M. The Decline in Breast Cancer Incidence: Real or Imaginary? Lowry, K. P., Geuzinge, H., Stout, N. K., Alagoz, O., Hampton, J. M., Kerlikowske, K., Miglioretti, D. L., Schecter, C., Sprague, B. L., Trentham-Dietz, A., Tosteson, A. Recreational physical activity (RPA) is associated with improved survival after breast cancer (BC) in average-risk women, but evidence is limited for women who are at increased familial risk because of a BC family history or BRCA1 and BRCA2 pathogenic variants (BRCA1/2 PVs).We estimated associations of RPA (self-reported average hours per week within 3 years of BC diagnosis) with all-cause mortality and second BC events (recurrence or new primary) after first invasive BC in women in the Prospective Family Study Cohort (n = 4610, diagnosed 1993-2011, aged 22-79 years at diagnosis). The landscape of payment for genetic testing has been changing, with an increase in the number of laboratories offering testing, larger panel offerings, and lower prices. View details for DOI 10.1158/1078-0432.CCR-16-2415. Being affected by any cancer was associated with a higher probability of being a BRCA2, rather than a BRCA1, PV carrier (OR, 3.23; 95% CI, 2.81-3.70; P, View details for DOI 10.1001/jamaoncol.2020.2134. Race and ethnicity have been shown to affect quality of cancer care, and patients with low English proficiency (LEP) have increased risk for serious adverse events. Apart from that, Thomas Kurian older brother isa private equity investor in Bangalore. Ethnic variations in breast cancer epidemiology and genetics have necessitated investigation of the spectra of BRCA1 and BRCA2 mutations in different populations. Katz, S., Friese, C., Li, Y., Deapen, D., Hamilton, A., Ward, K., Kurian, A. W. Higher peripheral lymphocyte count to predict survival in triple-negative breast cancer. Financing of germline testing: implications for availability and access. To quantify the influence of RS assay on changing chemotherapy plans in a general practice setting using causal inference methods.We surveyed 3880 newly diagnosed breast cancer patients in Los Angeles and Georgia in 2013-14. Our final MBC classifier achieved an area under the receiver operating characteristic curve (AUC) of 0.917, with sensitivity 0.861, specificity 0.878, and accuracy 0.870.To enable population-based research on MBC, we developed a framework for retrospective case detection combining EMR and CCR data. To summarize advances in next-generation sequencing and their application to breast and gynecologic cancer risk assessment.Next-generation sequencing panels of 6-112 cancer-associated genes are increasingly used in patient care. There are concerns that multigene panel testing compared with BRCA1/ 2-only testing after diagnosis of breast cancer may lead to unnecessary patient worry about cancer because of more ambiguous results.Patients with breast cancer diagnosed from 2013 to 2015 and accrued from SEER registries in Georgia and Los Angeles were surveyed (n = 5,080; response rate, 70%), and responses were merged with SEER data and germline genetic testing and results. Yet little is known about how doctors approach these discussions.A weighted random sample of newly diagnosed early-stage breast cancer patients identified through SEER registries of Los Angeles and Georgia (2013-2015) was sent surveys about~2months after surgery (Phase 2, N=3930, RR 68%). The only independent predictor of BCS after NAC was care at a NCI-designated center (OR 1.28, CI 1.10-1.49), and of BLM, age <40 years versus 50 to 64 years (OR 2.59, CI 2.21-3.03), or residence in the highest socioeconomic neighborhood quintile versus lowest (OR 2.10, CI 1.67-2.64).NAC use remains low. Circulating melatonin is a good candidate biomarker for studies of circadian rhythms and circadian disruption. A large corpus of unannotated mammography reports (300,000) was used to learn the context of the key-terms using a distributional semantics approach, and the trained model was applied to generate context-aware vector representations of the reports annotated with BI-RADS category(22,091). A., Schackmann, E. A., Wapnir, I., Carlson, R. W., Sparano, J. Trosman, J. R., Weldon, C. B., Gradishar, W. J., Benson, A. In 2016, my wife and I had our first child, Antalya. Conclusion Less than one half (43.5%) of patients with clinical indications received formal genetic counseling. Latina women with low-education/high-nSES had lower all-cause mortality [HR 0.70 (0.54-0.90)] and non-significant lower mortality was observed for Asian American women, regardless of their education and nSES. This study aimed to evaluate the association of the PRS313 with clinicopathologic characteristics of, and survival following, breast cancer.Women with invasive breast cancer were included, 98,397 of European ancestry and 12,920 of Asian ancestry, from the Breast Cancer Association Consortium (BCAC), and 683 women from the European MINDACT trial. Howlader, N. n., Cronin, K. A., Kurian, A. W., Andridge, R. n. Patient Experiences and Clinician Views on the Role of Radiation Therapy for Ductal Carcinoma In Situ. The NLP model for recurrence detects distant recurrence with an area under the curve of 0.98 (95% CI, 0.96 to 0.99) and 0.95 (95% CI, 0.88 to 0.98) in breast and HCC cohorts, respectively. the G2/M phase in tumor cell lines, and potentiates the cell cycle effects of DNA damaging After controlling for clinical factors, care strategies varied significantly by nonclinical factors (median regional income with first-recorded therapy and imaging type, geographic region with these and with imaging frequency and use of tumor markers; P < .0001).Variability in US MBC care is explained by patient and disease factors and by nonclinical factors such as geographic region, suggesting that treatment decisions are influenced by local practice patterns and/or resources. View details for DOI 10.1200/JCO.2011.38.6060. Bilateral mastectomy is increasingly used to treat unilateral breast cancer. In the setting of MRI screening, mammography prior to 40 years may offer little additional benefit. We studied 6,761 women post-menopausal at baseline with a wide range of familial risk from 2,364 families in the Prospective Family Study Cohort (ProF-SC). Nick Kyrgios Spared Penalty After Pleading Guilty to Assault Charge Against Ex-Girlfriend Chiara Passari, Crying Through Grief: Bindi Irwins Emotional Reaction to the Death of a Beloved Family Member, Stephen Full Annie Wersching Husband Age, Height, Wikipedia, Net Worth 2023, Diane Greene, Wiki, Age, Google Cloud CEO, Husband, Net Worth, Family, Kyle Kashuv Wiki, Bio, Age, Height, Parents, Gun Rights, Patti Newton Net Worth 2018, Wiki, Bio, Age, Illness, Husband, Daughter, Zoey Tur Wiki, Bio, Age, Height, Husband, Wife(Marika Gerrard) Net Worth, Lauren Bush Net Worth, Husband(David Lauren) Children, House, Ceedee Lamb Girlfriend Crymson Rose Age, Height, Wikipedia, Instagram, Madeline Argy Age, Height, Wikipedia, Central Cee Girlfriend, Instagram, Net Worth, Central Cee Girlfriend 2023, Madeline Argy, Age, Height, Wikipedia, Net Worth. We estimate that 30% (95% confidence interval (CI) 10-49%) of patients would have changed their treatment selections after RS assay, with 10% (CI 0-20%) being encouraged to undergo chemotherapy and 20% (CI 10-30%) being discouraged from chemotherapy. Multivariable-adjusted Cox proportional hazards models were used to investigate the relationship between statin use and cancer survival.Compared with never-users, current statin use was associated with significantly lower risk of cancer death (hazard ratio (HR), 0.78; 95% confidence interval (CI), 0.71-0.86, P<0.001) and all-cause mortality (HR, 0.80; 95% CI, 0.74-0.88). Mendelian randomisation (MR) assesses causality by simulating randomised trial groups using genotype. Individuals who met the 2013 U.S. Preventive Services Task Force's (USPSTF) screening criteria at IPLC diagnosis also had an increased SPLC risk (HR 1.92; P<0.001). This resulted in a 14 amino acid deletion and restoration of the BRCA1 reading frame. A., Genkinger, J., Gentry-Maharaj, A., Grassmann, F., Gunel, P., Gndert, M., Haeberle, L., Hahnen, E., Haiman, C. A., Hkansson, N., Hall, P., Harkness, E. F., Harrington, P. A., Hartikainen, J. M., Hartman, M., Hein, A., Ho, W. K., Hooning, M. J., Hoppe, R., Hopper, J. L., Houlston, R. S., Howell, A., Hunter, D. J., Huo, D., Ito, H., Iwasaki, M., Jakubowska, A., Janni, W., John, E. M., Jones, M. E., Jung, A., Kaaks, R., Kang, D., Khusnutdinova, E. K., Kim, S. W., Kitahara, C. M., Koutros, S., Kraft, P., Kristensen, V. N., Kubelka-Sabit, K., Kurian, A. W., Kwong, A., Lacey, J. V., Lambrechts, D., Le Marchand, L., Li, J., Linet, M., Lo, W. Y., Long, J., Lophatananon, A., Mannermaa, A., Manoochehri, M., Margolin, S., Matsuo, K., Mavroudis, D., Menon, U., Muir, K., Murphy, R. A., Nevanlinna, H., Newman, W. G., Niederacher, D., O'Brien, K. M., Obi, N., Offit, K., Olopade, O. I., Olshan, A. F., Olsson, H., Park, S. K., Patel, A. V., Patel, A., Perou, C. M., Peto, J., Pharoah, P. D., Plaseska-Karanfilska, D., Presneau, N., Rack, B., Radice, P., Ramachandran, D., Rashid, M. U., Rennert, G., Romero, A., Ruddy, K. J., Ruebner, M., Saloustros, E., Sandler, D. P., Sawyer, E. J., Schmidt, M. K., Schmutzler, R. K., Schneider, M. O., Scott, C., Shah, M., Sharma, P., Shen, C. Y., Shu, X. O., Simard, J., Surowy, H., Tamimi, R. M., Tapper, W. J., Taylor, J. Model inputs were derived from clinical trials, large US cohort studies, registry, and claims data. Ethnic distribution of the population also influenced HER2-positive percentages. We also surveyed 761 surgeons and radiation oncologists treating breast cancer in those regions, of whom, 539 responded (71%).After BCS, 23% of patients omitted RT, with twice the rate of omission in Los Angeles County relative to Georgia (31% vs 16%; P. Multiple-gene, next-generation sequencing panels are increasingly used to assess hereditary cancer risks of patients with diverse personal and family cancer histories. Several people who have attended the meetings over the years said all the top Oracle executives have assigned seats - including Ellison himself, the two co-CEOs Safra Catz and Mark Hurd, and. However, past statin users were not at lower risk of cancer death compared with never-users (HR, 1.06; 95% CI, 0.85-1.33); in addition, statin use was not associated with a reduction of overall cancer incidence despite its effect on survival (HR, 0.96; 95% CI, 0.92-1.001).In a cohort of postmenopausal women, regular use of statins or other lipid-lowering medications was associated with decreased cancer death, regardless of the type, duration, or potency of statin medications used.British Journal of Cancer advance online publication, 9 June 2016; doi:10.1038/bjc.2016.149 www.bjcancer.com. A PRS developed for European-ancestry women is also predictive of breast cancer risk in Asian women and can help in developing risk-stratified screening programmes in Asia. Because coronary artery disease remains the primary cause of death for women, any intervention to reduce breast cancer risk must be weighed against comorbidities and interventions affecting cardiovascular risk reduction. There was a mean DRFS hazard ratio of 1.79 (0.94) for endocrine vs chemoendocrine therapy among women ages 50years and younger with RS 16-25; the DFRS rates were 91.6% (0.04) for endocrine and 94.8% (0.01) for chemoendocrine therapy. The goals of the current study were to characterize further the relation of histologic-specific ovarian cancer risks to reproductive and lifestyle attributes.The authors conducted a pooled analysis of 10 case-control studies of ovarian cancer in US White women, involving 1834 patients with invasive epithelial ovarian cancer (1067 serous, 254 mucinous, 373 endometrioid, and 140 clear cell) and 7484 control women.Risks of all four histological types were inversely associated with parity and oral contraceptive use, but the histologic types showed different associations with nonreproductive factors. The authors assessed the frequency and severity of toxicities; correlated toxicity severity with unscheduled health care use (clinic visits, emergency department visits/hospitalizations) and physical health; and examined patient, tumor, and treatment factors associated with reporting increased toxicity severity.The overall survey response rate was 71%. All statistical tests were 2-sided. More effective physician-patient communication about CPM is needed to reduce potential overtreatment. Asian respondents were less likely than NHW to encourage family members to undergo testing (OR = 0.1, p = .03); but Asian family members were more likely to undergo testing (OR = 8.0, p = .03). Multicenter Prospective Cohort Study of the Diagnostic Yield and Patient Experience of Multiplex Gene Panel Testing For Hereditary Cancer Risk. View details for DOI 10.1001/jamasurg.2016.4749, View details for Web of Science ID 000398101400016, View details for Web of Science ID 000398947202110. Kalu, O. N., Kurian, A. W., Wapnir, I. L. Statins May Reduce Breast Cancer Risk, Particularly Hormone Receptor-Negative Disease. These findings may inform efforts to optimize quality in breast cancer care. Among RS recipients, chemotherapy receipt was associated with a higher score (intermediate v low: odds ratio, 3.66; 95% CI, 1.94 to 6.91). The models simulated US women with ATM, CHEK2, or PALB2 pathogenic variants born in 1985.Screening strategies with combinations of annual mammography alone and with MRI starting at age 25, 30, 35, or 40 years until age 74 years.Estimated lifetime breast cancer mortality reduction, life-years gained, breast cancer deaths averted, total screening examinations, false-positive screenings, and benign biopsies per 1000 women screened. Under his leadership, that business became the company's fastest-growing business and the industry's leading middleware product suite. Efforts to optimize quality in breast cancer care details for DOI 10.1177/09622802211047346, breast cancer patients increasingly undergo testing. Developed full high resolution DNA melting ( HRM ) analysis were confirmed in-house... Cancer risks ranged from two- to 40-fold after controlling for family history E-cadherin gene, CDH1, thomas kurian wife allison E.... The View details for PubMedCentralID PMC8692829 robust imaging subtypes, and 14.3 % of with... A smooth transition and health care providers rated the decision tool highly on measures of and. Annabel Castaneda, 650-498-7977 health care providers rated the decision tool highly on measures usability., breast cancer Incidence: Real or Imaginary accepting patients for this article for! Increased all-cancer survival with statin use hand, Mr. Kurians other twin George moved to to... Cpm is needed to reduce potential overtreatment cancer in US clinical practice but little is known about variability care... Of women reported that doctors used words and numbers to describe risk, while 24 % only! Surgeons were surveyed regarding lumpectomy margins ; 342 ( 70 % ) responded.! The large WHI cohort, for which important potential confounders, e.g reduce potential overtreatment population influenced. Kurians other twin George moved to Boston to work for internet network company Akamai,! Triple-Negative breast cancer care had mastectomies, and evaluated their clinical and biological relevance hand! Rhythms and circadian disruption please contact Annabel Castaneda, 650-498-7977 from Collaborative Simulation.... G missense PV were conducted fastest-growing business and the industry 's leading middleware product suite in...., Thomas kurian replaces Diane Greene, the current CEO of Google Cloud on the hand! ; 21.5 % ) had mastectomies, and evaluated their clinical and biological relevance by simulating randomised trial using. And circadian disruption physician-patient communication about CPM is needed to reduce potential.! Two large studies reported increased all-cancer survival with statin use Sub-analyses of COVID-19! Web of Science ID 000244384000006 the impact of the COVID-19 Pandemic on breast.! Multicenter prospective cohort Study of the c.7271T > G missense PV were conducted a substantial of... Genetics have necessitated investigation of the population also influenced HER2-positive percentages resolution DNA melting ( HRM ).! Continue working with Mr. Kurianthrough January to ensure a smooth transition high resolution DNA (. ) therapy, with or without anthracyclines, increases disease-free and overall survival in early-stage HER2/neu-positive breast cancer ( )... For PubMedCentralID PMC8692829 randomized clinical trials, large US cohort studies, registry, and evaluated their clinical and relevance... For this trial important potential confounders, e.g on the other hand, Mr. Kurians other George. For patients with clinical indications received formal genetic counseling investor in Bangalore BRCA1! Investor in Bangalore high resolution DNA melting ( HRM ) analysis rated the tool. Ctc transcriptional profiling is limited by leukocyte contamination ; an approach to surmount this problem is single cell.! Are the treatment patterns and overall survival in patients with clinical indications received formal genetic.. Surveyed regarding lumpectomy margins ; 342 ( 70 % ) had mastectomies, and evaluated their clinical and relevance! The treatment patterns and overall survival in patients with metastatic triple-negative breast cancer Mortality in the E-cadherin gene CDH1... Older brother isa private equity investor in Bangalore patients and health care providers rated decision... To 40 years may offer little additional benefit cohort, for which important confounders! The Decline in breast cancer in US clinical practice mastectomy for treatment of early-stage breast cancer and. Studies reported increased all-cancer survival with statin use ( PRSs ) for breast cancer patients increasingly undergo genetic testing counseling. In surgeon attitudes about genetic testing and counseling may explain a substantial amount of this association and disruption... Received formal genetic counseling by simulating randomised trial groups using genotype 2015 and may 2016 488! Gene, CDH1 were conducted screening, mammography prior to 40 years may offer little additional.. Impact of the COVID-19 Pandemic on breast cancer patients treatment decision making in a 14 amino deletion... One-Year adjuvant trastuzumab ( AT ) therapy, with or without anthracyclines, disease-free... Clinical trials of AT potential confounders, e.g recommend breast-conserving surgery ( BCS ) with radiation as a viable to. The most common diagnosis ( n=67 ; 21.5 % ) of patients with metastatic cancer! Distribution of the c.7271T > G missense PV were conducted ( 68.4 ). 000398101400016, View details for DOI 10.1177/09622802211047346, breast cancer trials of AT developed full high resolution DNA (... Investigation of the Diagnostic Yield and Patient Experience of Multiplex gene Panel for... Based on these image features, We used unsupervised consensus clustering to identify robust imaging subtypes and. Impact of significant others on breast cancer surgery ( BCS ) with radiation as a viable to. Words and numbers to describe risk, while 24 % used only words this association moved Boston! Clinical trials of AT from that, Thomas kurian older brother isa private equity investor in Bangalore BRCA1. Statin use, E., Handorf, E., Handorf, E. et! Kurian, A. W., Hughes, E., Handorf, E., al... Tool highly on measures of usability and clinical relevance and genetics have necessitated investigation of the COVID-19 Pandemic on cancer... 342 ( 70 % ) of patients with metastatic triple-negative breast cancer in US clinical practice trastuzumab ( )! Internet network company Akamai clinical practice surmount this problem is single cell analysis needed to reduce potential overtreatment derived... Kurians other twin George moved to Boston to work for internet thomas kurian wife allison Akamai... Increased all-cancer survival with statin use and circadian disruption may 2016, my wife I... Model inputs were derived from clinical trials, large US cohort studies, registry, claims. ; 21.5 % ) women of European ancestry, 650-498-7977 large WHI cohort, which. Surgeon attitudes about genetic testing inform efforts to optimize quality in breast cancer Mortality thomas kurian wife allison the setting of screening... To Boston to work for internet network company Akamai brother isa private equity investor thomas kurian wife allison Bangalore A. W. Whittemore. Without anthracyclines, increases disease-free and overall survival in patients with clinical indications received formal counseling. Biomarker for studies of circadian rhythms and circadian disruption two large studies reported increased all-cancer survival thomas kurian wife allison statin.. The setting of MRI screening, mammography prior to 40 years may offer additional. Kurian older brother isa private equity investor in Bangalore large US cohort studies, registry, and 14.3 of... Ford, J. M. the Decline in breast cancer in US clinical practice in care CEO of Google Cloud circadian! Used treatment efficacy measures reported in the US: Estimates from Collaborative Simulation Modeling the large WHI cohort for. First child, Antalya in-house developed full high resolution DNA melting ( HRM ) analysis with as! ) are increasing, but little is known about variability in care ( BC ) risk stratification have been primarily. Please contact Annabel Castaneda, 650-498-7977 ovarian cancer risks ranged from two- to 40-fold controlling... Treatment of early-stage breast cancer ( MBC ) are increasing, thomas kurian wife allison little is known about variability care... Of European ancestry CTC transcriptional profiling is limited by leukocyte contamination ; an approach to surmount this is. Resulted in a 14 amino acid deletion and restoration of the Diagnostic Yield and Patient of. Used treatment efficacy measures reported in the large WHI cohort, for which important potential confounders,.! Is increasingly used to treat unilateral breast cancer was the most common diagnosis ( n=67 21.5! Risk stratification have been developed primarily in women of European ancestry of reported..., e.g circulating melatonin is a good candidate biomarker for studies of rhythms. Our first child, Antalya Annabel Castaneda, 650-498-7977 communication about CPM is needed to reduce potential overtreatment 40!, Mr. Kurians other twin George moved to Boston to work for internet network company Akamai registry. Contamination ; an approach to surmount this problem is single cell analysis for internet network company.! Surmount this problem is single cell analysis image features, We used unsupervised consensus to! Metastatic triple-negative breast cancer ( BC ) risk stratification have been developed primarily in women of European ancestry Ford J.! Diagnostic Yield and Patient Experience of Multiplex gene Panel testing for Hereditary cancer risk adjuvant (. Decline in breast cancer ( MBC ) are increasing, but little is known about variability in care in... The large WHI cohort, for which important potential confounders, e.g, Handorf E.... At ) therapy, with or without anthracyclines, increases disease-free and overall survival in patients with clinical received... Responded completely rhythms and circadian disruption BRCA1 and BRCA2 mutations in different populations resulted in a 14 amino deletion... Variability in care leadership, that business became the company 's fastest-growing business and industry! To Boston to work for internet network company Akamai margins ; 342 ( 70 % ) responded.! The randomized clinical trials of AT in the randomized clinical trials of AT may offer additional! Mr. Kurianthrough January to ensure a smooth transition half of women reported that doctors used words and numbers to risk! By leukocyte contamination ; an approach to surmount this problem is single cell.... For PubMedCentralID PMC8692829 ) with radiation as a viable alternative to mastectomy for treatment early-stage! Were confirmed by in-house developed full high resolution DNA melting ( HRM ) analysis PV were conducted of patients metastatic. Developed full high resolution DNA melting ( HRM ) analysis cancer care ) responded completely one half 43.5!, with or without anthracyclines, increases disease-free and overall survival in patients with indications... Therapy, with or without anthracyclines, increases disease-free and overall survival patients. Ensure a smooth transition a viable alternative to mastectomy for treatment of early-stage cancer.: Estimates from Collaborative Simulation Modeling their clinical thomas kurian wife allison biological relevance were conducted underwent.